PASCV E-Journal Club
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8/8/2017
When: Tuesday, August 8, 2017
12:00 PM
Where: United States


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Comparison of the Analytical Sensitivity of Blood Donor Screening versus Diagnostic Molecular Tests for the Detection of Zika Virus RNA: A PASCV E-Journal Club Discussion


Moderator: 

Ryan Relich, Ph.D.; Indiana University Health Pathology Laboratory, Indianapolis, IN

 

Speakers: 
Justin Kreuter, M.D.; Mayo Clinic, Rochester, MN

Ryan Relich, Ph.D.; Indiana University Health Pathology Laboratory, Indianapolis, IN

 

Zika virus continues to circulate and remains a significant concern in the Americas.  Over the past year, multiple different nucleic acid amplification tests (NAATs) have been developed to detect Zika virus RNA, and these assays can be categorized as either blood donor screening tests for use in blood donation centers or as diagnostic assays for use in clinical virology laboratories.

 

A recent, international, multicenter study evaluated the analytical sensitivity of Zika virus NAATs for blood donor screening compared to those designed for diagnostic purposes. For this E-Journal Club, our three-member panel will discuss the results of this study, entitled “Relative analytical sensitivity of donor nucleic acid amplification technology screening and diagnostic real-time polymerase chain reaction assays for detection of Zika virus RNA” in the journal Transfusion 2017;57(3):734-747.


Upon completion of the webinar, the participant should be able to:

  • Describe the difference between NAATs for Zika virus RNA used in blood donor screening compared to diagnostic testing;
  • Discuss the difference in analytical sensitivity between NAATs for Zika virus RNA used for blood donor screening compared to diagnostic testing; and
  • List at least two ways in which analytical sensitivity can be increased for Zika virus RNA NAATs.

Level: Intermediate: 
Refresher course; some basic knowledge required; for the experienced staff technologist with some years of experience.


1.0 Contact Hours

PASCV is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. 

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