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In the News


Outbreak of Seoul Virus Associated with Home-based Rat-breeding Facilities in Wisconsin and Illinois
CDC Health Advisory Network has reported an outbreak of Seoul virus first diagnosed in a home-based rat breeder in Wisconsin. Trace-in investigation demonstrated six additional human cases associated with two Illinois rat-breeding facilities that shipped rats to the Wisconsin breeder. Trace-out investigation showed that rats from affected facilities were shipped to residents of Alabama, Arkansas, Colorado, Illinois, Indiana, Louisiana, Michigan, Minnesota, South Carolina, Tennessee, and Utah. In humans, most Seoul virus infections are asymptomatic or mild. Severe disease can occur in the form of hemorrhagic fever with renal syndrome similar to other hantaviruses like Sin Nombre virus. The virus is transmitted through exposure to aerosolized urine, droppings, or dust from nests/bedding of infected rats. Detection of Seoul virus RNA in blood and serology (IgM and IgG) are useful diagnostic tests. Virology laboratories in the affected states should be aware of the potential for this infection in their care populations.

FDA Decides Against Issuing Final Guidance on Over Laboratory Developed Tests LDT’s
Citing stakeholders’ requests for further discussion on appropriate oversight mechanisms and congressional interest in a potential legislative solution to oversight, the FDA has decided against enforcing broad discretionary oversight of LDTs. The agency has published a discussion paper outlining its proposal for phased-in, focused oversight of new and significantly modified high and moderate risk LDTs. 

FDA Issues Black Box Warning for Direct Acting Hepatitis C Antivirals (DAAs) Over Concerns for Reactivation of Hepatitis B Virus During DAA Treatment 

The U.S. Food and Drug Administration (FDA) has issued a black box warning for the DAAs used in the treatment of chronic hepatitis C virus. There have been reports in the literature and to the FDA of hepatitis B virus reactivation and several cases of fulminant hepatitis B in patients who are co-infected with hepatitis C virus and hepatitis B virus who begin anti-HCV DAA treatment. U.S. hepatitis C guidelines have been updated to include recommendations for hepatitis B virus testing prior initiation of DAA treatment and suppressive therapy for hepatitis B virus during DAA treatment for individuals who meet HBV treatment criteria. 


Influenza Resource Center

CDC Updates on Influenza Virus Activity in the U.S.


Pan American Health Organization's Influenza Situation in the Americas


World Health Organization's Global Surveillance


As the influenza season in South America is winding down, the World Health Organization is recommending that a new clade 6B influenza A H1N1 virus A/Michigan/45/2015 (H1N1) replace A/California/7/2009 (H1N1) pdm09-like virus


Zika Virus Resource Center


Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Persons with Possible Zika Virus Exposure – United States, September 2016

New Zika Virus Special Travel Considerations for 11 Southeast Asian Countries [Brunei, Burma (Myanmar), Cambodia, Indonesia, Laos, Malaysia, Maldives, Philippines, Thailand, Timor-Leste (East Timor), Vietnam] Posted by CDC

CDC Updates Guidance for Travel and Testing of Pregnant Women and Women of Reproductive Age for Zika Virus Infection Related to the Ongoing Investigation of Local Mosquito-borne Zika Virus Transmission in Miami-Dade County, Florida (HAN-00396)

MMWR Publication: Demographics and Clinical Characteristics of Children Aged 0-17 Years with Zika Virus Disease Acquired Postnatally – U.S., January 2015-July 2016


MMWR Publication: Preliminary Findings from an Investigation of Zika Virus Infection in a Patient with No Known Risk Factors – Utah 2016

Elsevier Zika Virus Resource Center

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