Webinar: Metagenomic and Host Response Sequencing for Diagnosis of Viral Infections
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Clinical metagenomic next-generation sequencing (mNGS) is a transformative technology for infectious disease diagnosis that enables detection of nearly all pathogens – viruses, bacteria, fungi, and parasites – in a single assay. We will discuss studies on the clinical utility of this approach in the microbiology laboratory for diagnosis of neurological, bloodborne, and respiratory viral infections in difficult-to-diagnose cases.

 Export to Your Calendar 12/10/2020
When: Thursday, December 10
12:00pm
Where: United States
Contact: Jess Warner
412-983-1158


Online registration is available until: 12/10/2020
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Registration Rates
Member | Free
Non-Member | $50

Webinar Description

 

Moderator:

Ted E. Schutzbank, PhD, D(ABMM), Meridian Bioscience, Cincinnati, OH

Speaker:

Charles Chiu, MD, PhD, Department of Laboratory Medicine and Medicine, Division of Infectious Diseases, UCSF School of Medicine, San Francisco, CA

 

Clinical metagenomic next-generation sequencing (mNGS) is a transformative technology for infectious disease diagnosis that enables detection of nearly all pathogens – viruses, bacteria, fungi, and parasites – in a single assay. We will discuss studies on the clinical utility of this approach in the microbiology laboratory for diagnosis of neurological, bloodborne, and respiratory viral infections in difficult-to-diagnose cases. By combining pocket-size nanopore sequencing with a real-time bioinformatics pipeline run on a laptop, diagnosis of infections can be made within minutes, with a <6-hour sample-to-answer turnaround time (an example of its use for viral disease surveillance in Antarctica will be presented). Concurrently, we have been using machine learning approaches on RNA-Seq data to identify panels of host biomarkers that can discriminate between infectious (bacterial, viral) and non-infectious (autoimmune) conditions, and have applied this to develop novel host-based diagnostics for the SARS-Cov-2 coronavirus. The power to simultaneously assay pathogen and host will facilitate accurate and timely diagnosis of viral infections.

 

Upon completion of the webinar, the participant should be able to: 

  • Discuss clinical metagenomic next-generation sequencing (mNGS) and how it is a transformative approach for diagnosis of viral infections

  • Describe nanopore sequencing and its potential point-of-care diagnostic applications

  • Identify how host response RNA sequencing is complementary to direct detection methods for viral diagnosis.

Level of Instruction - Intermediate




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